Advanced Diagnostic & Interventional Radiology Research Center | Correlations of T2* Mapping with delayed gadolinium MRI

COVID-19 pandemic

During the COVID-19 pandemic, the Radiology Research Center at Tehran University of Medical Sciences continued its research activities despite the challenges posed by the increased demand for CT scans of COVID-19 patients and the necessity of adhering to strict health protocols. This center played a crucial role in improving medical imaging techniques, optimizing diagnostic protocols, and advancing technologies related to CT scan image analysis.

Faculty members, researchers, and staff remained committed to ensuring the safety and well-being of healthcare professionals and patients while actively engaging in imaging data analysis, developing artificial intelligence algorithms for faster disease detection, publishing scientific articles, and presenting their findings at international conferences. These efforts aimed to enhance diagnostic accuracy, improve treatment processes, and alleviate pressure on healthcare systems.

Key achievements of the Radiology Research Center during the COVID-19 pandemic include:

✔️ Development and optimization of lung imaging protocols for faster and more accurate COVID-19 diagnosis
✔️ Implementation of artificial intelligence technologies for automated CT scan analysis and reduced diagnosis time
✔️ Publication of high-impact research articles on innovative imaging methods for COVID-19 patients
✔️ Participation in national and international projects focused on COVID-19 diagnosis and patient management

The center remains dedicated to advancing research in medical imaging and continues to contribute as a leading scientific institution in improving the quality of diagnostic and therapeutic services.

Correlations of T2* Mapping with delayed gadolinium enhancement in magnetic resonance imaging of chronic myocardial infarction

T2* Mapping with gadolinium enhancement in MRI myocardial infarction {faces}

Background:

Scar tissue formation is a common phenomenon in myocardial infarctions. Contrast-enhanced cardiac magnetic resonance imaging is the modality of choice to evaluate the location and size of the scar tissue. Nevertheless, in patients with severe kidney impairment, administration of gadolinium is contraindicated.

Objectives:

So the aim of this study was to substitute a safe way for myocardial infarction assessments in patients with a history of renal function impairment. We assessed the T2* quantitative value changes in myocardial infarction-related scar tissue and compared them with normal/remote myocardial tissue T2* values to evaluate its application in non-contrast cardiac magnetic resonance imaging viability assessments.

Patients and Methods:

Twenty patients with a previous history of non ST-elevation myocardial infarction (NSTEMI) underwent cardiac magnetic resonance (CMR) examination with a 1.5T MR imaging scanner (Avanto, Siemens AG Healthcare Sector, Erlangen, Germany). The time interval between myocardial infarction occurrence and CMR assessment was at least six months. All the patients had normal kidney function. The imaging protocol consisted of three steps: the functional left-ventricular imaging; 8-echoes gradient recalled echo T2* mapping; and delayed/late gadolinium-enhancement imaging. The left-ventricle functional and T2* mapping assessments were done by CMR42 image analysis software (Circle Cardiovascular Imaging, Calgary, Canada). T2* values were calculated for 49 regions of interests (ROIs) at the infarction (14 ROIs), peri-infarction (12 ROIs), and remote/normal myocardial tissues (23 ROIs), and their means were compared statistically by the Leven’s test. Finally, the receiver operator characteristics curve was calculated.

Results:

T2* (mean ± SD) values of the normal/remote, peri-infarction, and infarcted myocardial tissues were calculated as 29.42 ± 4.50, 30.71 ± 4.86, and 35.46 ± 3.61, respectively. There was a significant alteration in the post-infarction scar tissue’s myocardial T2* values by comparison with the normal/remote myocardium (P < 0.001). No significant differences were noticed between the normal/remote and peri-infarction regions’ T2* relaxation times (P > 0.05). Area under the curve was 81% for patients evaluated for scars. Cutoff value of 31.70 yielded 92% sensitivity and 72% specificity.

Conclusion:

T2* relaxation time can provide useful and sensitive information on scar tissue formation location, and can offer a greater sensitivity into the non-contrast CMR imaging viability assessments besides other relaxation phenomena, especially the longitudinal relaxation time.

Article_DOI : doi.org/10.5812/iranjradiol.12688
Author(s) : maryam mohammadzadeh,ali mohammadzadeh
News Group : research,research article
News Code : 278405

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Advanced Diagnostic & Interventional Radiology Research Center | Correlations of T2* Mapping with delayed gadolinium MRI

Advanced Diagnostic & Interventional Radiology Research Center

COVID-19 pandemic

Key achievements of the Radiology Research Center during the COVID-19 pandemic include:

Some of the center's significant achievements during the pandemic include: