Advanced Diagnostic & Interventional Radiology Research Center | novel lncRNA players in triple-negative breast cancer pathogenes

Advanced Diagnostic & Interventional Radiology Research Center | novel lncRNA players in triple-negative breast cancer pathogenes
| Dec 10 2025
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Advanced Diagnostic & Interventional Radiology Research Center

COVID-19 pandemic 

During the COVID-19 pandemic, the Radiology Research Center at Tehran University of Medical Sciences continued its research activities despite the challenges posed by the increased demand for CT scans of COVID-19 patients and the necessity of adhering to strict health protocols. This center played a crucial role in improving medical imaging techniques, optimizing diagnostic protocols, and advancing technologies related to CT scan image analysis.

Faculty members, researchers, and staff remained committed to ensuring the safety and well-being of healthcare professionals and patients while actively engaging in imaging data analysis, developing artificial intelligence algorithms for faster disease detection, publishing scientific articles, and presenting their findings at international conferences. These efforts aimed to enhance diagnostic accuracy, improve treatment processes, and alleviate pressure on healthcare systems.

 

Key achievements of the Radiology Research Center during the COVID-19 pandemic include:


✔️ Development and optimization of lung imaging protocols for faster and more accurate COVID-19 diagnosis
✔️ Implementation of artificial intelligence technologies for automated CT scan analysis and reduced diagnosis time
✔️ Publication of high-impact research articles on innovative imaging methods for COVID-19 patients
✔️ Participation in national and international projects focused on COVID-19 diagnosis and patient management

The center remains dedicated to advancing research in medical imaging and continues to contribute as a leading scientific institution in improving the quality of diagnostic and therapeutic services.

 

Some of the center's significant achievements during the pandemic include:

 

  • Release Date : Feb 17 2025 - 13:49
  • : 78
  • Study time : 1 minute(s)

SBF2 AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis

SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis {faces}

Background: Compared to other breast cancer subtypes, triple-negative breast cancer (TNBC) has always been challenging for clinicians due to its aggressive behavior and lack of a specific treatment. There is a confirmed association between invasive features of tumors and increased epithelial-mesenchymal transition (EMT) process, which is consistent with a higher rate of EMT in TNBC.

Methods and results: We investigated the expression of EMT-related genes, SNAI1 and MMP7, and EMT-related lncRNAs, treRNA and SBF2-AS1, in 50 TNBC tumors and 50 non-TNBC tumors to reveal more regulators and effectors involved in TNBC malignancy. In the present study, we showed the overexpression of all the studied genes and lncRNAs in TNBC tumors compared to non-TNBC samples. Moreover, a significant association was observed between MMP7 and treRNA expression levels and larger tumor size. A positive correlation between SNAI1 and lncRNA treRNA expression levels was also detected.

Conclusions: Due to the differential expression and the potential diagnostic power of the studied genes, SBF2-AS1 and treRNA can be proposed as new probable biomarkers and therapeutic targets in TNBC.

  • Article_DOI : 10.1007/s11033-023-08533-y
  • Author(s) : zeeba kamaliyan,reza mirfakhraie
  • News Group : research,research article
  • News Code : 293429
مدیر سیستم
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مدیر سیستم

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